Rajni- you bring up two important points:

– Asymptomatic elevations of amylase and lipase may or may not be clinically significant. These labs, if drawn, must be interpreted in context; and as Lisa states, “blanket” guidelines may results in unnecessary dose holds, or worse yet, unnecessary discontinuation.

– Thanks for pointing out that colitis does not always mean diarrhea! This can be tricky for providers less experienced with the GI effects.